X0306 4 2020-09-11 0 0001404281 Novus Therapeutics, Inc. NVUS 0001664784 Kuwahara Jon C/O NOVUS THERAPEUTICS, INC. 19900 MACARTHUR BLVD., SUITE 550 IRVINE CA 92612 0 1 0 0 See Remarks Stock Option (Right to Buy) 500.00 2020-09-11 4 A 0 2145.264 0.00 A 2030-09-11 Series X1 Convertible Preferred Stock 2145.264 2145.264 D This option represents a right to purchase a total of 2,145.264 shares of the Issuer's Series X1 Convertible Preferred Stock, one quarter of which will become fully vested and exercisable on September 11, 2021, with the remaining 1,608.948 shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The Reporting Person's ability to exercise the option will be subject to stockholder approval under Nasdaq Marketplace Rule 5635(c). Each share of Series X1 Convertible Preferred Stock will be convertible into 1,000 shares of Common Stock upon receipt of the requisite approval of the stockholders of the Issuer. Senior Vice President of Finance and Administration /s/ Ryan A. Murr, as attorney-in-fact for Jon Kuwahara 2020-09-15