X0306 4 2018-03-13 0 0001404281 Novus Therapeutics, Inc. NVUS 0001664784 Kuwahara Jon C/O NOVUS THERAPEUTICS, INC. 19900 MACARTHUR BLVD., SUITE 550 IRVINE CA 92612 0 1 0 0 See Remarks Common Stock 2018-03-13 4 A 0 11250 0.00 A 11250 D Stock Option (Right to Buy) 4.83 2018-03-13 4 A 0 12000 0.00 A 2028-03-13 Common Stock 12000 12000 D This represents restricted stock units representing the right to receive shares of the Issuer's Common Stock, which will vest in full on the later of achievement of a performance-related goal or the first anniversary of the grant date. This option represents a right to purchase a total of 12,000 shares of the Issuer's Common Stock, one quarter of which will become fully vested and exercisable on March 13, 2019, with the remaining 9,000 shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. Senior Vice President of Finance and Administration /s/ Ryan A. Murr, as attorney-in-fact for Jon Kuwahara 2018-03-15