Revenue from Contracts with Customers (Details) - USD ($) $ in Thousands		3 Months Ended	12 Months Ended
	Apr. 05, 2016	Mar. 31, 2022	Dec. 31, 2022	Dec. 31, 2021
Disaggregation of Revenue [Line Items]
Research collaboration revenue			$ 0	$ 20,100
MGH | License Agreement
Disaggregation of Revenue [Line Items]
Expiration period	10 years		10 years
License | Neurona Therapeutics, Inc.
Disaggregation of Revenue [Line Items]
Research collaboration revenue				100
License | Hansoh Shanghai Healthtech Co Ltd
Disaggregation of Revenue [Line Items]
Research collaboration revenue		$ 18,000
Revenue, remaining performance obligation, development milestones, variable consideration			$ 26,500
Revenue, remaining performance obligation, sales milestones, variable consideration amount			$ 144,000
Withholding taxes from upfront fee				2,000
Revenue from Contract with Customer, Including Assessed Tax				$ 20,000