Commitments and Contingencies - Narrative (Details)	1 Months Ended	3 Months Ended	12 Months Ended
	Mar. 31, 2017 USD ($)	Mar. 31, 2023	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Sep. 30, 2021 USD ($)	Sep. 07, 2021 USD ($) ft²	Aug. 31, 2021 ft²	Aug. 31, 2019 ft²
Lessee, Lease, Description [Line Items]
Operating lease right-of-use assets			$ 15,548,000	$ 1,067,000		$ 15,400,000
Operating lease liability			13,266,000			$ 12,900,000
Restricted cash			1,327,000	1,327,000
Tenant improvements			$ 400,000
Renewal term			5 years
Total lease cost			$ 1,100,000	600,000
Cash paid for operating leases			$ 900,000	600,000
Weighted average remaining lease term			4 years
Weighted average discount rate			10.00%
Short-term expenses			$ 23,627	5,089
Certificates of Deposit
Lessee, Lease, Description [Line Items]
Restricted cash			100,000	$ 100,000
99 Hayden Lease
Lessee, Lease, Description [Line Items]
Area of rental space (sqft) | ft²							15,622	10,417
Operating lease right-of-use assets					$ 700,000
Operating lease liability					$ 700,000
99 Hayden Lease | Loans Payable
Lessee, Lease, Description [Line Items]
Loan from landlord	$ 200,000
Interest rate	8.00%
Repayments related to loan			65,000
99 Hayden Lease | Loans Payable | Interest Only
Lessee, Lease, Description [Line Items]
Debt instrument, term	18 months
99 Hayden Lease | Loans Payable | Principal and Interest
Lessee, Lease, Description [Line Items]
Debt instrument, term	3 years 6 months
Waltham Lease
Lessee, Lease, Description [Line Items]
Area of rental space (sqft) | ft²						35,662
Lessee, operating lease, monthly base rent			$ 200,000
Percentage of annual increase in operating lease			3.00%
Letters of credit outstanding, amount			$ 1,200,000
Operating lease, period for improvement			8 years 4 months
Operating lease not yet commenced			$ 2,200,000
Vivarium Premises | Forecast
Lessee, Lease, Description [Line Items]
Lessee, operating lease, period after commencement date for which base rent is due		4 months