SCHEDULE 13G 0001230239 XXXXXXXX LIVE Common Stock, par value $0.0001 per share 12/31/2024 0001664710 Keros Therapeutics, Inc. 492327101 1050 WALTHAM STREET, SUITE 302 LEXINGTON MA 02421 Rule 13d-1(b) Alkeon Capital Management LLC DE 0.00 1101000.00 0.00 1101000.00 1101000.00 N 2.7 IA OO Panayotis D. Sparaggis X1 0.00 1101000.00 0.00 1101000.00 1101000.00 N 2.7 HC IN Keros Therapeutics, Inc. 1050 Waltham Street, Suite 302, Lexington MA 02421 This statement is filed by: (1) Alkeon Capital Management LLC ("Alkeon"), a Delaware limited liability company and the investment manager to certain funds (the "Alkeon Funds"), with respect to the shares of common stock, par value $0.0001 per share ("Common Stock"), of Keros Therapeutics, Inc. (the "Company") directly held by the Alkeon Funds; and (2) Panayotis D. Sparaggis ("Mr. Sparaggis") the Founder and Managing Director of Alkeon, with respect to the shares of Common Stock directly held by the Alkeon Funds. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities and Exchange Act of 1934, the beneficial owner of the shares of Common Stock reported herein. This filing constitutes Amendment No. 2 to the original Schedule 13G filed by the undersigned with the Securities and Exchange Commission (the "SEC") on February 13, 2023 (the "Original schedule 13G"), and as amended by Amendment No. 1 thereto filed by the undersigned with the SEC on February 13, 2024. However, this filing is being submitted as an initial Schedule 13G, rather than a Schedule 13G/A, in order to gain access to the EDGAR system under the structured data requirements applicable to Schedule 13G filings (effective December 18, 2024), which does not allow the undersigned to submit this filing as a Schedule 13G/A because the Original Schedule 13G was filed as a Schedule 13G/A. The address of the business office of each of the Reporting Persons is 350 Madison Avenue, 20th Floor, New York, NY 10017. The Investment Manager is a Delaware limited liability company. Mr. Sparaggis is a citizen of the United States. N IA HC The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentage set forth in this Schedule 13G is calculated based upon an aggregate of 40,507,409 shares of Common Stock outstanding as of October 31, 2024, as reported in the Company's Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2024 filed with the SEC on November 6, 2024. 2.7 The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. N Y N See Item 2. The Alkeon Funds have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the shares of Common Stock. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Alkeon Capital Management LLC /s/ Jennifer Shufro 02/14/2025 Panayotis D. Sparaggis /s/ Panayotis D. Sparaggis 02/14/2025