X0306 4 2019-03-06 0 0001346830 Cara Therapeutics, Inc. CARA 0001664708 Mohindru Mani C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA,107 ELM STREET, 9TH FL STAMFORD CT 06902 0 1 0 0 CFO & Chief Strategy Officer Employee Stock Option (Right to Buy) 16.10 2019-03-06 4 A 0 75000 0.00 A 2029-03-06 Common Stock 75000 75000 D The shares shall vest and become exercisable in a series of 48 successive equal monthly installments beginning on April 6, 2019, in each case subject to the Reporting Person's Continuous service (as that term is defined in the Issuer's 2014 Equity Incentive Plan) as of each such date. /s/Darren DeStefano, Attorney-in-Fact 2019-03-08