X0306 4 2018-12-28 0 0001346830 Cara Therapeutics, Inc. CARA 0001664708 Mohindru Mani C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA,107 ELM STREET, 9TH FL STAMFORD CT 06902 0 1 0 0 CFO & Chief Strategy Officer Common Stock 2018-12-28 4 S 0 4500 12.55 D 8026 D This sale was effected pursuant to a "sell to cover" arrangement adopted by the Reporting Person in accordance with Rule 10b5-1 on September 6, 2018 to satisfy the tax withholding obligations triggered by the vesting and of the restricted stock units reported in the Form 4 filed by the Reporting Person with the Securities and Exchange Commission on December 31, 2018, and does not represent a discretionary trade by the Reporting Person. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding described above. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.53 - $12.73, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) to this Form 4. /s/Darren DeStefano, Attorney-in-Fact 2019-01-02