X0306 4 2018-12-27 0 0001346830 Cara Therapeutics, Inc. CARA 0001664708 Mohindru Mani C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA,107 ELM STREET, 9TH FL STAMFORD CT 06902 0 1 0 0 CFO & Chief Strategy Officer Common Stock 2018-12-27 4 A 0 12526 0.00 A 12526 D Represents the vesting in full of a performance-based restricted stock unit award based on the Issuer's satisfaction of certain performance criteria. In light of the performance-based vesting conditions of the award, such award was not reportable under Section 16 until vesting was determined, which occurred on December 27, 2018. Each restricted stock unit represented the contingent right to receive one share of common stock of the Issuer. /s/Darren DeStefano, Attorney-in-Fact 2018-12-31