X0306 4 2018-10-17 0 0001346830 Cara Therapeutics, Inc. CARA 0001664708 Mohindru Mani C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA,107 ELM STREET, 9TH FL STAMFORD CT 06902 0 1 0 0 CFO & Chief Strategy Officer Common Stock 2018-10-17 4 M 0 16042 14.06 A 16042 D Common Stock 2018-10-17 4 S 0 16042 20.19 D 0 D Employee Stock Option (Right to Buy) 14.06 2018-10-17 4 M 0 16042 0.00 D 2027-08-15 Common Stock 16042 368958 D These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 7, 2018. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.72 - $20.70, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4. One-fourth (1/4th) of the shares subject to this option vested and became exercisable on August 15, 2018; the balance of the shares shall vest and become exercisable in a series of 36 successive equal monthly installments measured from August 15, 2018, subject to the reporting person's continuous service with the issuer as of each such date. /s/Darren DeStefano, Attorney-in-Fact 2018-10-19