X0508 4 2025-06-02 0 0000907654 Oruka Therapeutics, Inc. ORKA 0001802528 Fairmount Funds Management LLC 200 BARR HARBOR DRIVE SUITE 400 WEST CONSHOHOCKEN PA 19428 1 0 1 0 0001769651 Fairmount Healthcare Fund II L.P. 200 BARR HARBOR DRIVE SUITE 400 WEST CONSHOHOCKEN PA 19428 1 0 1 0 0002009690 Fairmount Healthcare Co-Invest III L.P. 200 BARR HARBOR DRIVE SUITE 400 WEST CONSHOHOCKEN PA 19428 1 0 0 0 0001663607 Harwin Peter Evan 200 BARR HARBOR DRIVE SUITE 400 WEST CONSHOHOCKEN PA 19428 1 0 1 0 0001830177 Kiselak Tomas 200 BARR HARBOR DRIVE SUITE 400 WEST CONSHOHOCKEN PA 19428 1 0 1 0 0 Stock Option (Right to Buy) 11.77 2025-06-02 4 A 0 17500 0 A 2035-06-01 Common Stock 17500 17500 I By: Peter Harwin This option represents a right to purchase 17,500 shares of the Issuer's common stock, which vests as to 1/12 of the option monthly from June 2, 2025, subject to the recipient's continued service to the Issuer. Under Mr. Harwin's arrangement with Fairmount Funds Management LLC ("Fairmount"), Mr. Harwin holds the option for one or more investment vehicles managed by Fairmount (each, a "Fairmount Fund"). Mr. Harwin is obligated to turn over to Fairmount any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Harwin therefore disclaims beneficial ownership of the option and underlying common stock. Fairmount disclaims beneficial ownership of any of the reported securities, except to the extent of its pecuniary interest therein. Fairmount, Fairmount Healthcare Fund II LP and Fairmount Healthcare Co-Invest III L.P. may each be deemed a director by deputization of the Issuer by virtue of the fact that Peter Harwin serves on the board of directors of the Issuer and is a manager of Fairmount. /s/ Peter Harwin, Managing Member of Fairmount Funds Management LLC 2025-06-03 /s/ Peter Harwin, Managing Member of Fairmount Healthcare Fund II L.P. 2025-06-03 /s/ Peter Harwin, Managing Member of Fairmount Healthcare Co-Invest III L.P 2025-06-03 /s/ Peter Harwin 2025-06-03 /s/ Tomas Kiselak 2025-06-03