X0508 4 2023-11-24 0001636282 Spyre Therapeutics, Inc. AGLE 0001802528 Fairmount Funds Management LLC 200 BARR HARBOR DRIVE, SUITE 400 WEST CONSHOHOCKEN PA 19428 true false true false 0001686157 Fairmount Healthcare Fund L.P. 200 BARR HARBOR DRIVE, SUITE 400 WEST CONSHOHOCKEN PA 19428 true false true false 0001769651 Fairmount Healthcare Fund II L.P. 200 BARR HARBOR DRIVE, SUITE 400 WEST CONSHOHOCKEN PA 19428 true false true false 0001982220 Fairmount Healthcare Co-Invest L.P. 200 BARR HARBOR DRIVE, SUITE 400 WEST CONSHOHOCKEN PA 19428 true false true false 0001830177 Kiselak Tomas 200 BARR HARBOR DRIVE, SUITE 400 WEST CONSHOHOCKEN PA 19428 true false true false 0001663607 Harwin Peter Evan 200 BARR HARBOR DRIVE, SUITE 400 WEST CONSHOHOCKEN PA 19428 true false true false false Common Stock 2023-11-24 4 C false 3435480 0 A 3435480 I By Fairmount Healthcare Co-Invest L.P. Common Stock 11043 I By Fairmount Healthcare Fund L.P. Common Stock 367378 I By Fairmount Healthcare Fund II L.P. Series A Preferred Stock 2023-11-24 4 C false 85887 0 D Common Stock 3435480 0 I By Fairmount Healthcare Co-Invest L.P. Series A Preferred Stock Common Stock 507000 12675 I By Fairmount Healthcare Fund L.P. Series A Preferred Stock Common Stock 16974480 424362 I By Fairmount Healthcare Fund II L.P. Following stockholder approval of the conversion of Series A preferred stock into shares of common stock, each share of Series A preferred stock automatically converted on November 24, 2023 into 40 shares of common stock, subject to certain beneficial ownership limitations. Fairmount Funds Management LLC ("Fairmount") is the investment manager for Fairmount Healthcare Fund L.P., Fairmount Healthcare Fund II L.P. and Fairmount Healthcare Co-Invest L.P. The general partner of Fairmount is Fairmount Funds Management GP LLC ("Fairmount GP"), of which Peter Harwin and Tomas Kiselak are the managing members. Fairmount, Fairmount GP, Mr. Harwin, and Mr. Kiselak disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein. The Reporting Persons may each be deemed a director by deputization of Issuer by virtue of the fact that each of Peter Harwin and Tomas Kiselak serve on the board of directors of Issuer and are also each a Managing Member of Fairmount Funds Management LLC. /s/ Tomas Kiselak, Managing Member of Fairmount Funds Management LLC 2023-11-28 /s/ Tomas Kiselak, Managing Member of Fairmount Healthcare Fund L.P. 2023-11-28 /s/ Tomas Kiselak, Managing Member of Fairmount Healthcare Fund II L.P. 2023-11-28 /s/ Tomas Kiselak, Managing Member of Fairmount Healthcare Co-Invest L.P. 2023-11-28 /s/ Tomas Kiselak 2023-11-28 /s/ Peter Harwin 2023-11-28