X0206 3 2018-03-16 0 0001373707 TETRAPHASE PHARMACEUTICALS INC TTPH 0001663605 Watt Christopher C/O TETRAPHASE PHARMACEUTICALS, INC. 480 ARSENAL STREET, SUITE 110 WATERTOWN MA 02472 0 1 0 0 SVP, Finance Common Stock 19114 D Employee Stock Options (Right to Buy) 50.49 2025-07-14 Common Stock 50000 D Employee Stock Option (Right to Buy) 8.47 2026-01-05 Common Stock 25000 D Employee Stock Option (Right to Buy) 3.69 2027-01-29 Common Stock 60000 D Employee Stock Option (Right to Buy) 6.24 2028-01-16 Common Stock 50000 D Restricted Stock Units Common Stock 12500 D Restricted Stock Units Common Stock 15000 D This option vests over four years. Twenty-five percent (25%)of the shares vested on July 15, 2016 and 6.25% of the shares will vest at the end of each successive three month period thereafter. Vests as to 6.25% of the shares on 4/6/2016 and further vests as to an additional 6.25% of the original grant at the end of each successive three-month period thereafter until 1/6/2020. Vests as to 6.25% of the shares on 4/30/2017 and further vests as to an additional 6.25% of the original grant at the end of each successive three-month period thereafter until 1/31/2021. Vests as to 6.25% of the shares on 4/17/2018 and further vests as to an additional 6.25% of the original grant at the end of each successive three-month period thereafter until 1/17/2022. The restricted stock units vest in three equal installments on each of January 6, 2017, January 6, 2018 and January 6, 2019. Each restricted stock unit represents a contingent right to receive one share of common stock of Tetraphase Pharmaceuticals, Inc. for no consideration. These restricted stock units shall be earned upon achievement of certain performance conditions and, if earned, shall vest on January 31, 2020. /s/Maria Stahl as Attorney-in-Fact for Christopher Watt 2018-03-20