X0206 3 2016-01-06 0 0001373707 TETRAPHASE PHARMACEUTICALS INC TTPH 0001663605 Watt Christopher C/O TETRAPHASE PHARMACEUTICALS, INC. 480 ARSENAL STREET, SUITE 110 WATERTOWN MA 02472 0 1 0 0 VP, Finance Employee Stock Options (Right to Buy) 50.49 2025-07-14 Common Stock 50000 D Restricted Stock Units Common Stock 14000 D This option vests over four years. Twenty-five percent (25%)of the shares will vest on July 15, 2016 and 6.25% of the shares will vest at the end of each successive three month period thereafter. The restricted stock units vest in full on October 1, 2016. Each restricted stock unit represents a contingent right to receive one share of common stock of Tetraphase Pharmaceuticals, Inc. for no consideration. /s/Maria Stahl as Attorney-in-Fact for Christopher Watt 2016-01-15