X0306 4 2017-12-22 0 0001649989 Oncobiologics, Inc. ONS 0001663252 Yamashita Elizabeth A. C/O ONCOBIOLOGICS, INC. 7 CLARKE DRIVE CRANBURY NJ 08512 0 1 0 0 VP, Regulatory Affairs Common Stock 2017-12-22 4 S 0 16170 1.13 D 64648 D Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the settlement of vested restricted stock units ("RSUs"). This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. Includes 21,739 shares of the Issuer's common stock subject to RSUs that will vest on 4/7/2018, subject to continued service through such date. /s/ Lawrence Kenyon, Attorney-in-Fact 2017-12-26