<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2016-01-08</periodOfReport>

    <issuer>
        <issuerCik>0001053691</issuerCik>
        <issuerName>RestorGenex Corp</issuerName>
        <issuerTradingSymbol>RESX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001663220</rptOwnerCik>
            <rptOwnerName>Byrne Thomas S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2020 AVON COURT, SUITE 4</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>CHARLOTTESVILLE</rptOwnerCity>
            <rptOwnerState>VA</rptOwnerState>
            <rptOwnerZipCode>22902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

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                <transactionShares>
                    <value>237422</value>
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    </derivativeTable>

    <footnotes>
        <footnote id="F1">Received in exchange for 381,056 units of Diffusion Pharmaceuticals LLC (&quot;Diffusion&quot;) in connection with the consummation of the merger (the &quot;Merger&quot;) of Diffusion and a wholly-owned subsidiary of the Issuer (&quot;Merger Sub&quot;) on January 8, 2016 based upon the exchange rate set forth in the Agreement and Plan of Merger, dated December 15, 2015, by and among the Issuer, Diffusion and Merger Sub.</footnote>
        <footnote id="F2">In connection with the consummation of the Merger, an option originally granted on May 17, 2012 to purchase membership units in Diffusion was converted into an option to purchase common stock of the Issuer.</footnote>
        <footnote id="F3">In connection with the consummation of the Merger, an option originally granted on October 9, 2012 to purchase membership units in Diffusion was converted into an option to purchase common stock of the Issuer.</footnote>
        <footnote id="F4">The shares underlying the options vest in equal parts each month until fully vested on the third anniversary of the grant date.</footnote>
        <footnote id="F5">In connection with the consummation of the Merger, an option originally granted on October 5, 2013 to purchase membership units in Diffusion was converted into an option to purchase common stock of the Issuer.</footnote>
        <footnote id="F6">In connection with the consummation of the Merger, an option originally granted on December 1, 2014 to purchase membership units in Diffusion was converted into an option to purchase common stock of the Issuer.</footnote>
        <footnote id="F7">In connection with the consummation of the Merger, an option originally granted on October 30, 2015 to purchase membership units in Diffusion was converted into an option to purchase common stock of the Issuer.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Ben Shealy, attorney-in-fact for Thomas Byrne</signatureName>
        <signatureDate>2016-01-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
