<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-04-20</periodOfReport>

    <issuer>
        <issuerCik>0000880242</issuerCik>
        <issuerName>BIOLARGO, INC.</issuerName>
        <issuerTradingSymbol>BLGO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001663146</rptOwnerCik>
            <rptOwnerName>STROMMEN JACK B.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>7108 31ST AVENUE NORTH</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MINNEAPOLIS</rptOwnerCity>
            <rptOwnerState>MN</rptOwnerState>
            <rptOwnerZipCode>55427</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common stock</value>
            </securityTitle>
            <transactionDate>
                <value>2021-04-20</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>C</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>563035</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.24</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4878579</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The securities acquired reported herein were issued as payment of principal and interest due on a convertible promissory note issued on March 28, 2018, in the principal amount of $100,000, held by Sanatio Capital, LLC, an entity owned/controlled by Reporting Person.</footnote>
        <footnote id="F2">Of this amount, 570,567 shares are held by Sanatio Capital, LLC, an entity owned/controlled by the Reporting Person.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ John R. Browning, Attorney-in-fact</signatureName>
        <signatureDate>2021-04-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
