X0306 4 2022-03-03 0 0001662774 Cortexyme, Inc. CRTX 0001674232 McDowell Caryn Gordon C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Legal & Adm. Officer Common Stock 2022-03-03 4 A 0 140000 0.00 A 140000 D Represents grant of Restricted Stock Units (the "RSU Award") payable solely in common stock of the Issuer. The shares subject to the RSU Award shall vest in equal quarterly installments over two years, with 1/8th of the total number of shares subject to the RSU Award vesting on each quarterly anniversary of the date of grant. /s/ Caryn Gordon McDowell 2022-03-03