X0306 4 2021-11-12 0 0001662774 Cortexyme, Inc. CRTX 0001770860 Dominy Stephen S. C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 1 0 0 Chief Scientific Officer Common Stock 2021-11-12 4 P 0 763 14.40 A 1217086 I By the Dominy Family Trust 2016 Common Stock 220588 I By The Stephen Dominy 2019 Annuity Trust Stephen S. Dominy is a trustee of the Dominy Family Trust 2016, and shares voting and dispositive power with one other trustee with respect to the shares held of record by the Dominy Family Trust 2016. Stephen S. Dominy is the trustee of the Stephen Dominy 2019 Annuity Trust, and has sole voting and dispositive power with respect to the shares held of record by the Stephen Dominy 2019 Annuity Trust. /s/ Caryn Gordon McDowell, as Attorney-in-Fact for Stephen S. Dominy 2021-11-12