X0306 4 2021-05-10 0 0001662774 Cortexyme, Inc. CRTX 0001770783 Lynch Casey C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 1 0 0 Chief Executive Officer Common Stock 2021-05-10 4 S 0 13584 33.75 D 995190 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 Common Stock 2021-05-10 4 S 0 9918 34.89 D 985272 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 Common Stock 2021-05-10 4 S 0 6315 35.81 D 978957 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 Common Stock 2021-05-10 4 S 0 183 36.73 D 978774 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 Common Stock 49895 D Common Stock 91911 I By The Casey C. Lynch 2019 Annuity Trust The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 29, 2020 and amended on December 18, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.41 to $34.40, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. Casey C. Lynch is a trustee of the Zachary and Casey Lynch Living Trust dated February 24, 2009, and shares voting and dispositive power with one other trustee with respect to the shares held of record by the Zachary and Casey Lynch Living Trust dated February 24, 2009. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.41 to $35.37, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.44 to $36.04, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. Casey C. Lynch is the trustee of The Casey C. Lynch 2019 Annuity Trust, and holds sole voting and dispositive power with respect to the shares held of record by The Casey C. Lynch 2019 Annuity Trust. /s/ Caryn Gordon McDowell, as Attorney-in-Fact for Casey C. Lynch 2021-05-11