X0306 4 2021-03-04 0 0001662774 Cortexyme, Inc. CRTX 0001770790 Lamond David C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2021-03-04 5 G 0 E 1534720 0.00 A 1534720 I By David A. Lamond Trust dated 2006 Common Stock 1797109 I By Blue Devil Trust dated 12/03/2010 Common Stock 301829 D On March 4, 2021, in accordance with the provisions of a Grantor Retained Annuity Trust (the "GRAT"), 1,534,720 shares were distributed from the GRAT to the David A. Lamond Trust dated 2006 for the benefit of the Reporting Person. Mr. Lamond is the trustee of David A. Lamond Trust dated 2006 (the "2006 Trust") and holds sole voting and dispositive power with respect to the shares held of record by the 2006 Trust. Mr. Lamond is the trustee of Blue Devil Trust dated 12/03/2010 (the "Trust") and holds sole voting and dispositive power with respect to the shares held of record by the Trust. /s/ Caryn Gordon McDowell, as Attorney-in-Fact for David Lamond 2021-03-23