X0206 3 2021-02-09 0 0001662774 Cortexyme, Inc. CRTX 0001606905 Monohon Ted C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Accounting Officer Employee Stock Option (right to buy) 6.91 2029-02-05 Common Stock 55147 D Employee Stock Option (right to buy) 54.85 2030-02-05 Common Stock 40000 D Employee Stock Option (right to buy) 29.60 2030-12-10 Common Stock 45000 D 25% of the shares underlying this option shall vest on the first annual anniversary of the vesting commencement date and 1/48th of the shares underlying this option shall vest monthly thereafter over 36 months. The shares subject to the option vest in 48 equal monthly installments from the vesting commencement date. /s/ Caryn McDowell, Attorney-in-Fact for Ted Monohon 2021-02-09