X0306 4 2021-02-09 0 0001662774 Cortexyme, Inc. CRTX 0001376260 LOWE CHRISTOPHER P. C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 COO & Chief Financial Officer Employee Stock Option (right to buy) 46.10 2021-02-09 4 A 0 40000 0.00 A 2031-02-08 Common Stock 40000 40000 D 1/48th of the total number of shares subject to the Option shall vest and become exercisable on each monthly anniversary of the vesting start date (and if there is no corresponding day, the last day of the month). /s/ Caryn McDowell, Attorney-in-Fact for Christopher Lowe 2021-02-11