X0306 4 2020-05-15 0 0001662774 Cortexyme, Inc. CRTX 0001770790 Lamond David C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2020-05-15 4 P 0 1263 46.3007 A 1654599 I By Blue Devil Trust dated 12/03/2010 Common Stock 2020-05-15 4 P 0 985 48.365 A 1655584 I By Blue Devil Trust dated 12/03/2010 Common Stock 2020-05-15 4 P 0 1600 48.9584 A 1657184 I By Blue Devil Trust dated 12/03/2010 Common Stock 2020-05-15 4 P 0 1000 50.7073 A 1658184 I By Blue Devil Trust dated 12/03/2010 Common Stock 2020-05-15 4 P 0 500 52.201 A 1658684 I By Blue Devil Trust dated 12/03/2010 Common Stock 2020-05-15 4 P 0 100 53.10 A 1658784 I By Blue Devil Trust dated 12/03/2010 Common Stock 2020-05-19 4 P 0 400 54.09 A 1659184 I By Blue Devil Trust dated 12/03/2010 Common Stock 2020-05-19 4 P 0 5906 55.4197 A 1665090 I By Blue Devil Trust dated 12/03/2010 Common Stock 2020-05-19 4 P 0 32894 56.4157 A 1697984 I By Blue Devil Trust dated 12/03/2010 Common Stock 301829 D The range of prices for the shares of Common Stock is from $45.80 to $46.75. The reporting person undertakes that he will provide, upon request by the staff of the U.S. Securities and Exchange Commission, full information regarding the number of securities purchased at each separate price. Mr. Lamond is the trustee of Blue Devil Trust dated 12/03/2010 (the "Trust") and holds sole voting and dispositive power with respect to the shares held of record by the Trust. The range of prices for the shares of Common Stock is from $47.68 to $48.64. The reporting person undertakes that he will provide, upon request by the staff of the U.S. Securities and Exchange Commission, full information regarding the number of securities purchased at each separate price. The range of prices for the shares of Common Stock is from $48.70 to $49.625. The reporting person undertakes that he will provide, upon request by the staff of the U.S. Securities and Exchange Commission, full information regarding the number of securities purchased at each separate price. The range of prices for the shares of Common Stock is from $50.38 to $51.36. The reporting person undertakes that he will provide, upon request by the staff of the U.S. Securities and Exchange Commission, full information regarding the number of securities purchased at each separate price. The range of prices for the shares of Common Stock is from $51.95 to $52.57. The reporting person undertakes that he will provide, upon request by the staff of the U.S. Securities and Exchange Commission, full information regarding the number of securities purchased at each separate price. The range of prices for the shares of Common Stock is from $53.65 to $54.53. The reporting person undertakes that he will provide, upon request by the staff of the U.S. Securities and Exchange Commission, full information regarding the number of securities purchased at each separate price. The range of prices for the shares of Common Stock is from $54.895 to $55.77. The reporting person undertakes that he will provide, upon request by the staff of the U.S. Securities and Exchange Commission, full information regarding the number of securities purchased at each separate price. The range of prices for the shares of Common Stock is from $55.90 to $56.87. The reporting person undertakes that he will provide, upon request by the staff of the U.S. Securities and Exchange Commission, full information regarding the number of securities purchased at each separate price. /s/ Christopher P. Lowe, as Attorney-in-Fact for David Lamond 2020-05-19