X0206 3 2020-05-05 1 0001662774 Cortexyme, Inc. CRTX 0001674232 McDowell Caryn Gordon C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Legal & Adm. Officer No securities beneficially owned. Exhibit 24.1: Power of Attorney /s/ Caryn Gordon McDowell 2020-05-14