X0306 4 2019-05-13 0 0001662774 Cortexyme, Inc. CRTX 0001255349 RYAN UNA S C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2019-05-13 4 P 0 2875 17.00 A 2875 I Una S. Ryan Revocable Trust Shares reported herein are held of record by the Una S. Ryan Revocable Trust. Ms. Ryan is one of the trustees of the Una S. Ryan Revocable Trust, and has shared voting and dispositive power with respect to the shares held of record by the Una S. Ryan Revocable Trust. /s/ Christopher Lowe, as attorney-in-fact for Una S. Ryan 2020-03-12