X0306 4 2019-08-15 0 0001662774 Cortexyme, Inc. CRTX 0001770840 Gafric Kristen C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 SVP, Legal & Administration Employee Stock Option (Right to Buy) 28.71 2019-08-15 4 A 0 75000 0.00 A Common Stock 75000 75000 D 1/48th of the total number of shares subject to this option will vest and become exercisable on each monthly anniversary of the vesting start date, beginning February 1, 2019, and for so long as the Reporting Person remains a Service Provider (as defined in the Issuer's Stock Plan). /s/ Kristen Gafric 2019-08-15