X0206 3 2019-05-08 0 0001662774 Cortexyme, Inc. CRTX 0001770860 Dominy Stephen S. C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 1 1 0 0 Chief Scientific Officer Common Stock 220588 I By The Stephen Dominy 2019 Annuity Trust Common Stock 1216323 I By the Dominy Family Trust 2016 Stock Option (right to buy) 0.41 2026-11-17 Common Stock 133055 D Stock Option (right to buy) 2.23 2028-10-29 Common Stock 118051 D Stephen S. Dominy is the trustee of the Stephen Dominy 2019 Annuity Trust, and has sole voting and dispositive power with respect to the shares held of record by the Stephen Dominy 2019 Annuity Trust. Stephen S. Dominy is a trustee of the Dominy Family Trust 2016, and shares voting and dispositive power with one other trustee with respect to the shares held of record by the Dominy Family Trust 2016. The option vested as to 1/48th of the shares on July 15, 2016, with the remaining shares vesting in equal monthly installments beginning on August 15, 2016 and ending on June 15, 2020. The option vested as to 1/48th of the shares on October 1, 2018, with the remaining shares vesting in equal monthly installments beginning on November 1, 2018 and ending on September 1, 2022. Exhibit 24.1: Power of Attorney /s/ Christopher Lowe, as Attorney-in-Fact for Stephen S. Dominy 2019-05-08