X0202 SCHEDULE 13G 0001932516 XXXXXXXX LIVE Common Stock 10/06/2026 0001662774 IRulya Therapeutics Inc. 22053A305 611 Gateway Boulevard, Suite 273 South San Francisco CA 94080 Rule 13d-1(c) Foresite Capital Fund VI LP b DE 489029.00 0.00 489029.00 0.00 489029.00 N 4.5 PN Note to Row 5: 489,029 shares*, except that Foresite Capital Management VI, LLC ("FCM VI"), the general partner of Foresite Capital Fund VI LP ("FCF VI"), may be deemed to have sole power to vote these shares, and James B. Tananbaum ("Tananbaum"), the managing member of FCM VI, may be deemed to have sole power to vote these shares. Note to Row 6: See response to row 5. Note to Row 7: 489,029* shares, except that FCM VI, the general partner of FCF VI, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 10,841,470 shares of Common Stock outstanding of IRulya Therapeutics Inc. (the "Issuer") as of October 9, 2026, as set forth in the Issuer's press release on October 9, 2026. *Represents shares of Series C Preferred Stock owned by FCF VI on an as-converted basis. Foresite Capital Management VI, LLC b DE 489029.00 0.00 489029.00 0.00 489029.00 N 4.5 OO Note to Row 5: 489,029 shares*, all of which are directly owned by FCF VI. FCM VI, the general partner of FCF VI, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to vote these shares. Note to Row 6: See response to row 5. Note to Row 7: 489,029 shares*, all of which are directly owned by FCF VI. FCM VI, the general partner of FCF VI, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM VI, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 10,841,470 shares of Common Stock outstanding of the Issuer as of October 9, 2026, as set forth in the Issuer's press release on October 9, 2026. *Represents shares of Series C Preferred Stock owned by FCF VI on an as-converted basis. Foresite Public & Crossover Opportunities Fund I, L.P. b DE 163010.00 0.00 163010.00 0.00 163010.00 N 1.5 PN Note to Row 5: 163,010 shares*, except that Foresite Public & Crossover Opportunities Management I, LLC ("FPCOM"), the general partner of Foresite Public & Crossover Opportunities Fund I, L.P. ("FPCOF"), may be deemed to have sole power to vote these shares, and James B. Tananbaum ("Tananbaum"), the managing member of FPCOM, may be deemed to have sole power to vote these shares. Note to Row 6: See response to row 5. Note to Row 7: 163,010 shares*, except that FPCOM, the general partner of FPCOF, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FPCOM, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 10,841,470 shares of Common Stock outstanding of the Issuer as of October 9, 2026, as set forth in the Issuer's press release on October 9, 2026. *Represents shares of Series C Preferred Stock owned by FPCOF on an as-converted basis. Foresite Public & Crossover Opportunities Management I, LLC b DE 163010.00 0.00 163010.00 0.00 163010.00 N 1.5 OO Note to Row 5: 163,010 shares*, all of which are directly owned by FPCOF. FPCOM, the general partner of FPCOF, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FPCOM, may be deemed to have sole power to vote these shares. Note to Row 6: See response to row 5. Note to Row 7: 163,010 shares*, all of which are directly owned by FPCOF. FPCOM, the general partner of FPCOF, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FPCOM, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 10,841,470 shares of Common Stock outstanding of the Issuer as of October 9, 2026, as set forth in the Issuer's press release on October 9, 2026. *Represents shares of Series C Preferred Stock owned by FPCOF on an as-converted basis. James B. Tananbaum b X1 652039.00 0.00 652039.00 0.00 652039.00 N 6.0 IN Note to Row 5: 652,039 shares*, of which 489,029 shares are directly owned by FCF VI and 163,010 shares are directly owned by FPCOF. Tananbaum is the managing member of FCM VI, which is the general partner of FCF VI, and the managing member of FPCOM, which is the general partner of FPCOF. Tananbaum may be deemed to have sole power to vote these shares. Note to Row 6: See response to row 5. Note to Row 7: 652,039 shares*, of which 489,029 shares are directly owned by FCF VI and 163,010 shares are directly owned by FPCOF. Tananbaum is the managing member of FCM VI, which is the general partner of FCF VI, and the managing member of FPCOM, which is the general partner of FPCOF. Tananbaum may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to row 7. Note to Row 11: This percentage is calculated based upon 10,841,470 shares of Common Stock outstanding of the Issuer as of October 9, 2026, as set forth in the Issuer's press release on October 9, 2026. *Represents shares of Series C Preferred Stock owned by FCF VI and FPCOF on an as-converted basis. IRulya Therapeutics Inc. 611 Gateway Boulevard, Suite 273, South San Francisco, CA 94080 This Schedule is filed by FCF VI, FCM VI, FPCOF, FPCOM and Tananbaum. The foregoing entities and individuals are collectively referred to as the "Reporting Persons." c/o Foresite Capital Management 9200 Sunset Boulevard, Suite PH1 West Hollywood, CA, 90069 See Row 4 of cover page for each Reporting Person. Y See Row 9 of cover page for each Reporting Person. See Row 11 of cover page for each Reporting Person. See Row 5 of cover page for each Reporting Person. See Row 6 of cover page for each Reporting Person. See Row 7 of cover page for each Reporting Person. See Row 8 of cover page for each Reporting Person. Y N Under certain circumstances set forth in the limited partnership agreement of FCF VI, the limited liability company agreement of FCM VI, the limited partnership agreement of FPCOF, and the limited liability company agreement of FPCOM, the partners or members, as the case may be, of each of such entities may be deemed to have the right to receive dividends from, or the proceeds from the sale of, shares of the Issuer directly or indirectly owned by each such entity of which they are a partner or member. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit A Agreement of Joint Filing The undersigned hereby agree that a single Schedule 13G (or any amendment thereto) relating to the Common Stock of the Issuer shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13G. Date: October 14, 2026 FORESITE CAPITAL FUND VI LP By: FORESITE CAPITAL MANAGEMENT VI, LLC Its: General Partner By: /s/ James B. Tananbaum Name: James B. Tananbaum Title: Managing Member FORESITE CAPITAL MANAGEMENT VI, LLC By: /s/ James B. Tananbaum Name: James B. Tananbaum Title: Managing Member FORESITE PUBLIC & CROSSOVER OPPORTUNITIES FUND I, L.P. By: FORESITE PUBLIC & CROSSOVER OPPORTUNITIES MANAGEMENT I, LLC Its: General Partner By: /s/ James B. Tananbaum Name: James B. Tananbaum Title: Managing Member FORESITE PUBLIC & CROSSOVER OPPORTUNITIES MANAGEMENT I, LLC By: /s/ James B. Tananbaum Name: James B. Tananbaum Title: Managing Member JAMES B. TANANBAUM By: /s/ James B. Tananbaum Foresite Capital Fund VI LP /s/ James B. Tananbaum 10/14/2026 Foresite Capital Management VI, LLC /s/ James B. Tananbaum 10/14/2026 Foresite Public & Crossover Opportunities Fund I, L.P. /s/ James B. Tananbaum 10/14/2026 Foresite Public & Crossover Opportunities Management I, LLC /s/ James B. Tananbaum 10/14/2026 James B. Tananbaum /s/ James B. Tananbaum 10/14/2026