Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2025

Share-Based Payment Arrangement [Abstract]

Schedule of Stock Options Activity

Activity for service-based stock options under the Quince 2019 Plan is as follows:

	Number of Options and Unvested Shares			Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
								(In thousands)
Balance as of December 31, 2024		7,408,005		$	3.16		8.37	$	4,285
Options granted		3,217,256			1.58	—		—
Options exercised		(184,060	)		1.00	—			120
Options cancelled / forfeited		(138,439	)		1.04	—		—
Balance as of June 30, 2025		10,302,762		$	2.73		8.46	$	2,807
Options vested and expected to vest as of June 30, 2025		10,302,762			2.73		8.46		2,807
Options exercisable as of June 30, 2025		3,887,846		$	4.92		7.72	$	1,156

Activity for service-based stock options under the 2019 Novosteo Plan is as follows:

	Number of Options and Unvested Shares		Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
							(In thousands)
Balance as of December 31, 2024		163,839	$	0.55		7.23	$	216
Options granted		—		—		—		—
Options exercised		—		—		—		—
Options cancelled / forfeited		—		—		—		—
Balance as of June 30, 2025		163,839	$	0.55		6.73	$	180
Options vested and expected to vest as of June 30, 2025		163,839		0.55		6.73		180
Options exercisable as of June 30, 2025		105,632	$	0.55		6.73	$	116

Activity for service-based stock options under the 2022 Inducement Plan is as follows:

	Number of Options and Unvested Shares		Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
							(In thousands)
Balance as of December 31, 2024		2,333,306	$	2.98		7.39		—
Options granted		—		—		—		—
Options exercised		—		—		—		—
Options cancelled / forfeited		—		—		—		—
Balance as of June 30, 2025		2,333,306	$	2.98		6.90		—
Options vested and expected to vest as of June 30, 2025		2,333,306		2.98		6.90		—
Options exercisable as of June 30, 2025		1,798,589	$	2.98		6.90		—

Schedule of Nonvested Restricted Stock Shares Activity

Restricted Stock Awards

	Restricted Stock Awards Outstanding
	Number of Shares			Weighted Average Grant Date Fair Value
Unvested - December 31, 2024		78,417		$	3.30
RSAs granted		—			—
RSAs vested		(48,672	)		3.30
RSAs cancelled		—			—
Unvested - June 30, 2025		29,745		$	3.30

Schedule of Employee and Non-Employee Stock-Based Compensation Expense

The following table summarizes employee and non-employee stock-based compensation expense for the three and six months ended June 30, 2025 and 2024 and the allocation within the consolidated statements of operations and comprehensive loss (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2025		2024		2025		2024
General and administrative expense	$	835	$	1,142	$	1,785	$	2,310
Research and development expense		438		81		874		187
Total stock-based compensation	$	1,273	$	1,223	$	2,659	$	2,497