Equity Incentive Plans - Summary of Activity for Service-based Stock Options (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Aggregate Intrinsic Value	$ 1,393,000	$ 22,512,000
2022 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Options and Unvested Shares, exercised	0
Aggregate Intrinsic Value	$ 0
Novosteo
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Aggregate Intrinsic Value	$ 0	$ 0
Service Based Stock Options | 2019 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Options and Unvested Shares, beginning balance	5,571,293	4,790,327
Number of Options and Unvested Shares, granted	2,051,058	1,436,116
Number of Options and Unvested Shares, exercised	(102,152)	(531,190)
Number of Options and Unvested Shares, Options cancelled / forfeited	(4,200,488)	(123,960)
Number of Options and Unvested Shares, ending balance	3,319,711	5,571,293	4,790,327
Number of Options and Unvested Shares, vested and expected to vest	3,319,711
Number of Options and Unvested Shares, exercisable	2,209,330
Weighted Average Exercise Price, beginning balance	$ 28.70	$ 25.47
Weighted Average Exercise Price, granted	8.13	35.20
Weighted Average Exercise Price, exercised	1.45	12.82
Weighted Average Exercise Price, cancelled/forfeited	29.30	47.09
Weighted Average Exercise Price, ending balance	16.07	$ 28.70	$ 25.47
Weighted Average Exercise Price, vested and expected to vest	16.07
Weighted Average Exercise Price, exercisable	$ 20.13
Weighted Average Remaining Contractual Life	4 years 9 months 7 days	8 years 3 months 3 days	8 years 8 months 8 days
Weighted Average Remaining Contractual Life, vested and expected to vest	4 years 9 months 7 days
Weighted Average Remaining Contractual Life, exercisable	2 years 6 months 7 days
Aggregate Intrinsic Value	$ 65,000	$ 15,687,000	$ 49,723,000
Aggregate Intrinsic Value, vested and expected to vest	65,000
Aggregate Intrinsic Value, exercisable	$ 65,000
Service Based Stock Options | 2022 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Options and Unvested Shares, granted	3,744,255
Number of Options and Unvested Shares, Options cancelled / forfeited	(2,000)
Number of Options and Unvested Shares, ending balance	3,742,255
Number of Options and Unvested Shares, vested and expected to vest	3,742,255
Weighted Average Exercise Price, granted		$ 2.98
Weighted Average Exercise Price, cancelled/forfeited	$ 2.98
Weighted Average Exercise Price, ending balance	2.98
Weighted Average Exercise Price, vested and expected to vest	$ 2.98
Weighted Average Remaining Contractual Life	9 years 4 months 20 days
Weighted Average Remaining Contractual Life, vested and expected to vest	9 years 4 months 20 days
Service Based Stock Options | Novosteo
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Options and Unvested Shares, assumed	507,648
Number of Options and Unvested Shares, Options cancelled / forfeited	(4,543)
Number of Options and Unvested Shares, ending balance	503,105
Number of Options and Unvested Shares, vested and expected to vest	503,105
Weighted Average Exercise Price, assumed	$ 0.55
Weighted Average Exercise Price, cancelled/forfeited	0.55
Weighted Average Exercise Price, ending balance	0.55
Weighted Average Exercise Price, vested and expected to vest	$ 0.55
Weighted Average Remaining Contractual Life	9 years 2 months 23 days
Weighted Average Remaining Contractual Life, vested and expected to vest	9 years 2 months 23 days
Aggregate Intrinsic Value	$ 44,000
Aggregate Intrinsic Value, vested and expected to vest	$ 44,000