Stock-Based Compensation - Summary of Activity for Service-based Stock Options (Details) - Service Based Stock Options $ / shares in Units, $ in Thousands	9 Months Ended	12 Months Ended
	Sep. 30, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares
2019 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Options and Unvested Shares, beginning balance	5,571,293
Number of Options and Unvested Shares, granted	2,014,058
Number of Options and Unvested Shares, exercised	(102,152)
Number of Options and Unvested Shares, cancelled / forfeited	(3,329,572)
Number of Options and Unvested Shares, ending balance	4,153,627	5,571,293
Number of Options and Unvested Shares, vested and expected to vest	4,153,627
Number of Options and Unvested Shares, exercisable	2,498,842
Weighted Average Exercise Price, beginning balance | $ / shares	$ 28.70
Weighted Average Exercise Price, granted | $ / shares	8.26
Weighted Average Exercise Price, exercised | $ / shares	1.45
Weighted Average Exercise Price, exercised, cancelled / forfeited | $ / shares	30.46
Weighted Average Exercise Price, ending balance | $ / shares	18.06	$ 28.70
Weighted Average Exercise Price, vested and expected to vest | $ / shares	18.06
Weighted Average Exercise Price, exercisable | $ / shares	$ 20.81
Weighted average remaining contractual life	5 years 7 months 24 days	8 years 3 months 3 days
Weighted average remaining contractual life, vested and expected to vest	5 years 7 months 24 days
Weighted average remaining contractual life, exercisable	3 years 3 months 21 days
Aggregate intrinsic value | $	$ 238	$ 15,687
Aggregate intrinsic value, exercised | $	(286)
Aggregate intrinsic value, vested and expected to vest | $	238
Aggregate intrinsic value, exercisable | $	$ 238
2022 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Options and Unvested Shares, granted	3,744,255
Number of Options and Unvested Shares, cancelled / forfeited	(2,000)
Number of Options and Unvested Shares, ending balance	3,742,255
Number of Options and Unvested Shares, vested and expected to vest	3,742,255
Weighted Average Exercise Price, exercised, cancelled / forfeited | $ / shares	$ 2.98
Weighted Average Exercise Price, ending balance | $ / shares	2.98
Weighted Average Exercise Price, vested and expected to vest | $ / shares	$ 2.98
Weighted average remaining contractual life	9 years 7 months 24 days
Weighted average remaining contractual life, vested and expected to vest	9 years 7 months 24 days
Novosteo
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Options and Unvested Shares, granted	507,648
Number of Options and Unvested Shares, cancelled / forfeited	(4,543)
Number of Options and Unvested Shares, ending balance	503,105
Number of Options and Unvested Shares, vested and expected to vest	503,105
Weighted Average Exercise Price, granted | $ / shares	$ 0.55
Weighted Average Exercise Price, exercised, cancelled / forfeited | $ / shares	0.55
Weighted Average Exercise Price, ending balance | $ / shares	0.55
Weighted Average Exercise Price, vested and expected to vest | $ / shares	$ 0.55
Weighted average remaining contractual life	9 years 5 months 23 days
Weighted average remaining contractual life, vested and expected to vest	9 years 5 months 23 days
Aggregate intrinsic value | $	$ 392
Aggregate intrinsic value, vested and expected to vest | $	$ 392