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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Cash flows from operating activities    
Net Loss $ (38,205,000) $ (44,840,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Non-cash rent expense 0 188,000
Stock based compensation 14,292,000 13,741,000
Depreciation and amortization 122,000 173,000
Impairment loss 98,000 0
Loss on disposal of fixed assets 77,000 0
Amortization of premium on available for sale investments 175,000 442,000
Change in deferred tax liabilities due to acquisition of Novosteo Inc. (284,000) 0
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,750,000 (1,851,000)
Other assets 147,000 (106,000)
Accounts payable (4,664,000) 3,638,000
Accrued expenses and other current liabilities (5,014,000) (2,557,000)
Net cash used in operating activities (31,506,000) (31,172,000)
Cash flow from investing activities:    
Purchase of investments (36,849,000) (25,165,000)
Proceeds from maturities of investments 34,388,000 62,568,000
Cash acquired from Novosteo Inc 10,593,000 0
Proceeds from disposal of assets 35,000 0
Purchase of property and equipment (5,000) (136,000)
Net cash provided by investing activities 8,162,000 37,267,000
Cash flows from financing activities:    
Payments of finance leases (12,000) 0
Proceeds from issuance of common stock upon exercise of stock options 134,000 1,113,000
Proceeds from issuance of common stock in connection with open market sales agreement, net of issuance costs 608,000 0
Net cash provided by financing activities 730,000 1,113,000
Effect of exchange rate changes on cash (182,000) 0
Net increase (decrease) in cash and cash equivalents (22,796,000) 7,208,000
Cash and cash equivalents at beginning of period 69,724,000 66,841,000
Cash and cash equivalents at end of period 46,928,000 74,049,000
Supplemental disclosures of non-cash information:    
Net assets acquired of Novosteo Inc. in exchange for common stock 16,210,000 0
Right-of-use assets obtained in exchange for new operating lease liabilities 256,000 1,210,000
Right Of Use Asset And Operating Lease Liability Reduction As A Result Of Lease Modification $ (640,000) $ 0