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Stock-Based Compensation - Summary of Activity for Service-based Stock Options (Details) - Service Based Stock Options - USD ($)
$ / shares in Units, $ in Thousands
6 Months Ended 12 Months Ended
Jun. 30, 2022
Dec. 31, 2021
2019 Plan    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Number of Options and Unvested Shares, beginning balance 5,571,293  
Number of Options and Unvested Shares, granted 1,869,058  
Number of Options and Unvested Shares, exercised (78,210)  
Number of Options and Unvested Shares, cancelled / forfeited (2,235,768)  
Number of Options and Unvested Shares, ending balance 5,126,373 5,571,293
Number of Options and Unvested Shares, vested and expected to vest 5,126,373  
Number of Options and Unvested Shares, exercisable 2,680,564  
Weighted Average Exercise Price, beginning balance $ 28.70  
Weighted Average Exercise Price, granted 8.75  
Weighted Average Exercise Price, exercised 1.72  
Weighted Average Exercise Price, exercised, cancelled / forfeited 30.39  
Weighted Average Exercise Price, ending balance 21.10 $ 28.70
Weighted Average Exercise Price, vested and expected to vest 21.10  
Weighted Average Exercise Price, exercisable $ 22.00  
Weighted average remaining contractual life 6 years 7 months 17 days 8 years 3 months 3 days
Weighted average remaining contractual life, vested and expected to vest 6 years 7 months 17 days  
Weighted average remaining contractual life, exercisable 4 years 5 months 26 days  
Aggregate intrinsic value $ 501 $ 15,687
Aggregate intrinsic value, vested and expected to vest 501  
Aggregate intrinsic value, exercisable $ 501  
2022 Inducement Plan    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Number of Options and Unvested Shares, granted 3,744,255  
Number of Options and Unvested Shares, ending balance 3,744,255  
Number of Options and Unvested Shares, vested and expected to vest 3,744,255  
Weighted Average Exercise Price, granted $ 2.98  
Weighted Average Exercise Price, ending balance 2.98  
Weighted Average Exercise Price, vested and expected to vest $ 2.98  
Weighted average remaining contractual life 9 years 10 months 24 days  
Weighted average remaining contractual life, vested and expected to vest 9 years 10 months 24 days  
Novosteo    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Number of Options and Unvested Shares, granted 507,648  
Number of Options and Unvested Shares, ending balance 507,648  
Number of Options and Unvested Shares, vested and expected to vest 507,648  
Weighted Average Exercise Price, granted $ 0.55  
Weighted Average Exercise Price, ending balance 0.55  
Weighted Average Exercise Price, vested and expected to vest $ 0.55  
Weighted average remaining contractual life 9 years 8 months 23 days  
Weighted average remaining contractual life, vested and expected to vest 9 years 8 months 23 days  
Aggregate intrinsic value $ 848  
Aggregate intrinsic value, vested and expected to vest $ 848