Summary of Employee and Non-Employee Stock-Based Compensation Expense

The following table summarizes employee and non-employee stock-based compensation expense for the three and six months ended June 30, 2022 and 2021 and the allocation within the condensed consolidated statements of operations and comprehensive loss (in thousands):


	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
General and administrative expense	$	3,267	$	3,629	$	7,699	$	7,108
Research and development expense		1,784		3,121		6,593		6,633
Total stock-based compensation	$	5,051	$	6,750	$	14,292	$	13,741

Activity for service-based stock options under the Quince 2019 Plan is as follows:


	Number of Options and Unvested Shares			Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
								(In thousands)
Balance at December 31, 2021		5,571,293		$	28.70		8.26	$	15,687
Options granted		1,869,058			8.75
Options exercised		(78,210	)		1.72
Options cancelled / forfeited		(2,235,768	)		30.39
Balance at June 30, 2022		5,126,373		$	21.10		6.63	$	501
Options vested and expected to vest as of June 30, 2022		5,126,373			21.10		6.63		501
Options exercisable as of June 30, 2022		2,680,564		$	22.00		4.49	$	501

Summary of Stock Options Activity

Activity for service-based stock options under the 2019 Novosteo Plan is as follows:


	Number of Options and Unvested Shares		Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
							(In thousands)
Balance at December 31, 2021		—		—		—		—
Options granted		507,648		0.55		—		—
Options exercised		—		—		—		—
Options cancelled / forfeited		—		—		—		—
Balance at June 30, 2022		507,648	$	0.55		9.73	$	848
Options vested and expected to vest as of June 30, 2022		507,648		0.55		9.73		848
Options exercisable as of June 30, 2022		—		—		—		—

Summary of Stock Options Activity

The following table summarizes activity under the Company’s PSOs from the Quince 2019 Plan and related information:


	Shares Subject to Outstanding PSOs			Weighted Average Exercise Price		Weighted average remaining contractual life (years)
Balance at December 31, 2021		675,000		$	29.60		5.74
Surrendered		(675,000	)	$	29.60	—
Vested	—			—		—
Balance at June 30, 2022	—			—		—

Summary of Restricted Stock Options

The following table summarizes activity under the Company’s RSUs from the Quince 2019 Plan and related information:


	Quince 2019 Plan
	Restricted Stock Units Outstanding
	Number of Shares			Weighted Average Grant Date Fair Value
Unvested - December 31, 2021	—			—
RSUs granted		1,013,500		$	4.30
RSUs vested		(253,297	)	$	4.30
RSUs cancelled		(226,538	)	$	4.30
Unvested - June 30, 2022		533,665		$	4.30

Summary of Stock Options Activity

Activity for service-based stock options under the 2022 Inducement Plan is as follows:


	Number of Options and Unvested Shares		Weighted Average Exercise Price		Weighted average remaining contractual life (years)		Aggregate intrinsic value
							(In thousands)
Balance at December 31, 2021		—		—		—		—
Options granted		3,744,255		2.98		—		—
Options exercised		—		—		—		—
Options cancelled / forfeited		—		—		—		—
Balance at June 30, 2022		3,744,255	$	2.98		9.90	$	—
Options vested and expected to vest as of June 30, 2022		3,744,255		2.98		9.90		—
Options exercisable as of June 30, 2022		—		—		—		—