X0306 4 2020-06-03 1 0001662774 Cortexyme, Inc. CRTX 0000078003 PFIZER INC 235 E 42ND ST NEW YORK NY 10017 0 0 1 0 0001776115 Pfizer Strategic Investment Holdings LLC 235 EAST 42ND STREET NEW YORK NY 10017 0 0 1 0 0001776087 Pfizer Ventures (US) LLC 235 EAST 42ND STREET NEW YORK NY 10017 0 0 1 0 Common Stock 2020-06-03 4 S 0 370000 40.18 D 2879973 D All of the shares disposed of were sold by Pfizer Inc. ("Pfizer") Represents 2,410,071 shares held of record by Pfizer Ventures (US) LLC, a controlled affiliate of Pfizer, 254,205 shares held of record by Pfizer, and 215,697 shares held of record by Pfizer Strategic Investment Holdings LLC, a controlled affiliate of Pfizer. Each Reporting Person disclaims beneficial ownership of securities reported on this Form 4, except to the extent of its respective pecuniary interest therein. Pfizer Inc., By /s/ Susan Grant, Assistant Secretary 2020-06-04 Pfizer Strategic Investment Holdings LLC By Susan Grant, Secretary 2020-06-04 Pfizer Ventures (US) LLC by /s/ Susan Grant, Secretary 2020-06-04