Nature of the business and basis of presentation (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2026	Mar. 31, 2025	Dec. 31, 2025
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 25,129	$ 26,322
Accumulated deficit	763,822		$ 738,693
Cash, cash equivalents and marketable securities	$ 268,300