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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table
Year (1)
Summary
Compensation
Table Total
for PEO
Compensation
Actually Paid
to PEO(2)
Average Summary
Compensation
Table Total for
Non-PEO NEOs
Average
Compensation
Actually Paid to
Non-PEO NEOs(2)
Total
Shareholder
Return(3)
Net Loss
(in thousands)
2025$2,940,975 $1,318,782 $1,559,294 $846,679 $32.37 $(104,994)
20244,633,005 905,032 2,289,149 1,138,076 61.02 (105,316)
20233,790,099 4,335,040 1,604,322 1,956,302 95.76 (132,493)
    
Named Executive Officers, Footnote The PEO for each of the periods presented is Mr. Hirsch. The Non-PEO NEOs were Ms Adams and Dr. Reyno for 2025, Dr. Mahaney and Dr. Reyno for 2024, and Dr. Reyno and Stewart Fisher, Ph.D., our then-Chief Scientific Officer, for 2023. The proxy statement for the 2025 Annual Meeting of Stockholders (the “2025 Proxy Statement”) inadvertently included Ms. Adams instead of Dr. Mahaney as a Non-PEO NEO for 2024 due to a clerical error in the preparation of the 2025 Proxy Statement. Upon further analysis, we have confirmed that this error impacted only the preparation of the 2025 Proxy Statement, and the Non-PEO NEOs identified therein, and there was no impact otherwise to the internal or external reporting of executive compensation or the analyses we or our OLCC have conducted. The amounts in the Pay Versus Performance tables, footnotes and disclosure have been corrected to include the compensation payable to Dr. Mahaney.    
PEO Total Compensation Amount $ 2,940,975 $ 4,633,005 $ 3,790,099
PEO Actually Paid Compensation Amount $ 1,318,782 905,032 4,335,040
Adjustment To PEO Compensation, Footnote These amounts are computed in accordance with Item 402(v) of Regulation S-K by deducting and adding the following amounts from the “Total” column of the SCT (pursuant to SEC rules, fair value at each measurement date is computed in a manner consistent with the fair value methodology used to account for share-based payments in our financial statements under GAAP). Prior year numbers have been adjusted for negligible differences that existed due to minor clerical errors:
202520242023
PEOAverage Non-PEO NEOsPEOAverage Non-PEO NEOsPEOAverage Non-PEO NEOs
Total Compensation from Summary Compensation Table$2,940,975 $1,559,294 $4,633,005 $2,289,149 $3,790,099 $1,604,322 
Adjustments for Equity Awards
Adjustments for grant date fair values of equity awards granted in the current year(1,558,737)(607,278)(3,551,880)(1,711,722)(2,804,021)(891,745)
Year-end fair value of unvested equity awards granted in the current year785,237 305,940 1,208,104 779,525 4,110,779 1,369,869 
Year-over-year difference of year-end fair values for unvested equity awards granted in prior years(638,655)(328,787)(1,732,748)(234,977)(198,377)(34,029)
Fair values at vest date for equity awards granted and vested in current year98,354 38,308 308,683 54,806 106,718 17,814 
Difference in fair values between prior year-end fair values and vest date fair values for equity awards granted in prior years(308,392)(120,798)39,868 (38,705)(670,158)(109,929)
Total Adjustments for Equity Awards(1,622,193)(712,615)(3,727,973)(1,151,073)544,941 351,980 
Compensation Actually Paid (as calculated)$1,318,782 $846,679 $905,032 $1,138,076 $4,335,040 $1,956,302 
    
Non-PEO NEO Average Total Compensation Amount $ 1,559,294 2,289,149 1,604,322
Non-PEO NEO Average Compensation Actually Paid Amount $ 846,679 1,138,076 1,956,302
Adjustment to Non-PEO NEO Compensation Footnote These amounts are computed in accordance with Item 402(v) of Regulation S-K by deducting and adding the following amounts from the “Total” column of the SCT (pursuant to SEC rules, fair value at each measurement date is computed in a manner consistent with the fair value methodology used to account for share-based payments in our financial statements under GAAP). Prior year numbers have been adjusted for negligible differences that existed due to minor clerical errors:
202520242023
PEOAverage Non-PEO NEOsPEOAverage Non-PEO NEOsPEOAverage Non-PEO NEOs
Total Compensation from Summary Compensation Table$2,940,975 $1,559,294 $4,633,005 $2,289,149 $3,790,099 $1,604,322 
Adjustments for Equity Awards
Adjustments for grant date fair values of equity awards granted in the current year(1,558,737)(607,278)(3,551,880)(1,711,722)(2,804,021)(891,745)
Year-end fair value of unvested equity awards granted in the current year785,237 305,940 1,208,104 779,525 4,110,779 1,369,869 
Year-over-year difference of year-end fair values for unvested equity awards granted in prior years(638,655)(328,787)(1,732,748)(234,977)(198,377)(34,029)
Fair values at vest date for equity awards granted and vested in current year98,354 38,308 308,683 54,806 106,718 17,814 
Difference in fair values between prior year-end fair values and vest date fair values for equity awards granted in prior years(308,392)(120,798)39,868 (38,705)(670,158)(109,929)
Total Adjustments for Equity Awards(1,622,193)(712,615)(3,727,973)(1,151,073)544,941 351,980 
Compensation Actually Paid (as calculated)$1,318,782 $846,679 $905,032 $1,138,076 $4,335,040 $1,956,302 
    
Compensation Actually Paid vs. Total Shareholder Return
2021
    
Compensation Actually Paid vs. Net Income
2023
    
Total Shareholder Return Vs Peer Group
2021
    
Total Shareholder Return Amount $ 32.37 61.02 95.76
Net Income (Loss) $ (104,994,000) (105,316,000) (132,493,000)
PEO Name Mr. Hirsch    
Additional 402(v) Disclosure
The following table sets forth information regarding “compensation actually paid” to our principal executive officer, or PEO, Mr. Hirsch, and to our non-PEO NEOs for each applicable year. The identity of our NEOs other than Mr. Hirsch may vary year-over-year and the identity of which NEOs are included in this table is determined based on those executive officers who were NEOs for the years presented. Compensation actually paid to Mr. Hirsch and our other NEOs is impacted by the fair value of their equity incentive awards, which is calculated in accordance with the provisions of FASB ASC Topic 718, Compensation—Stock Compensation. See Note 2 to our audited consolidated financial statements appearing in our 2025 Annual Report for a summary of the assumptions underlying the valuation of equity awards.
Shareholder return provides the value of common stock as of December 31, 2025, December 31, 2024, and December 31, 2023 assuming $100 was invested in our common stock after the market closed on December 31, 2022. 		   
PEO      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (1,622,193) (3,727,973) 544,941
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (1,558,737) (3,551,880) (2,804,021)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 785,237 1,208,104 4,110,779
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (638,655) (1,732,748) (198,377)
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 98,354 308,683 106,718
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (308,392) 39,868 (670,158)
Non-PEO NEO      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (712,615) (1,151,073) 351,980
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (607,278) (1,711,722) (891,745)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 305,940 779,525 1,369,869
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (328,787) (234,977) (34,029)
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 38,308 54,806 17,814
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (120,798) $ (38,705) $ (109,929)