Collaboration and license agreements - Merck, KGaA Agreement (Details) $ in Thousands			1 Months Ended
	Mar. 01, 2024 USD ($) target	May 29, 2023	Apr. 30, 2025 USD ($)	Dec. 31, 2025 USD ($) performanceObligation target	Dec. 31, 2024 USD ($)	Dec. 31, 2018 performanceObligation
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of performance obligations | performanceObligation						12
Transaction price allocated to performance obligation				$ 23,231
Contract with customer, liability				$ 28,334	$ 47,169
Minimum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Written notice period for termination of agreement		90 days
Merck, KGaA Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payment	$ 16,000
Regulatory milestone achieved			$ 1,000
Collaborative Arrangement, Addition To The Transaction Price			$ 1,000
Number Of Remaining Research And Development Targets | target				1
Number of performance obligations | performanceObligation				2
Transaction price allocated to performance obligation				$ 17,000
Number of remaining performance obligations | performanceObligation				1
Contract with customer, liability				$ 3,913	$ 13,373
Merck, KGaA Agreement | Minimum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Written notice period for termination of agreement	60 days
Merck, KGaA Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of potential research and development targets | target	2			2
Discovery, Regulatory, and Commercial Milestones | Merck, KGaA Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Amount eligible to receive	$ 740,000