Nature of the business and basis of presentation (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Dec. 31, 2024
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 52,342	$ 46,077
Accumulated deficit	686,041		$ 633,699
Cash, cash equivalents and marketable securities	$ 223,000