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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table
Year (1)
Summary
Compensation
Table Total
for PEO
Compensation
Actually Paid
to PEO(2)
Average Summary
Compensation
Table Total for
Non-PEO NEOs
Average
Compensation
Actually Paid to
Non-PEO NEOs(2)
Total
Shareholder
Return(3)
Net Loss
(in thousands)
2024$5,239,784 $867,532 $2,255,795 $858,463 $10.87 $(105,316)
20233,790,099 4,311,539 1,604,322 1,945,825 17.05 (132,493)
20222,595,395 (21,606,202)3,509,439 (2,156,954)17.81 (128,175)
    
Named Executive Officers, Footnote The PEO for each of the periods presented is Mr. Hirsch. The Non-PEO NEOs for 2024 were Dr, Reyno and Ms. Adams, for 2023 were Dr. Reyno and Stewart Fisher, Ph.D., our then-Chief Scientific Officer, and for 2022 were Dr. Scott Boyle, our Chief Business Officer, and Dr. Fisher.    
PEO Total Compensation Amount $ 5,239,784 $ 3,790,099 $ 2,595,395
PEO Actually Paid Compensation Amount $ 867,532 4,311,539 (21,606,202)
Adjustment To PEO Compensation, Footnote These amounts are computed in accordance with Item 402(v) of Regulation S-K by deducting and adding the following amounts from the “Total” column of the SCT (pursuant to SEC rules, fair value at each measurement date is computed in a manner consistent with the fair value methodology used to account for share-based payments in our financial statements under GAAP):
202420232022
PEOAverage Non-PEO NEOsPEOAverage Non-PEO NEOsPEOAverage Non-PEO NEOs
Total Compensation from Summary Compensation Table$5,239,784 $2,255,795 $3,790,099 $1,604,322 $2,595,395 $3,509,439 
Adjustments for Equity Awards
Adjustments for grant date fair values of equity awards granted in the current year(4,158,659)(1,481,447)(2,804,021)(891,745)(1,624,400)(2,844,379)
Year-end fair value of unvested equity awards granted in the current year1,208,104 428,267 4,110,779 1,362,669 284,900 356,546 
Year-over-year difference of year-end fair values for unvested equity awards granted in prior years(1,732,748)(412,318)(198,377)(34,088)(18,018,970)(2,349,947)
Fair values at vest date for equity awards granted and vested in current year308,683 109,509 106,718 17,814 158,875 104,252 
Difference in fair values between prior year-end fair values and vest date fair values for equity awards granted in prior years2,368 (41,343)(693,659)(113,147)(5,002,002)(932,865)
Total Adjustments for Equity Awards(4,372,252)(1,397,332)521,440 341,503 (24,201,597)(5,666,393)
Compensation Actually Paid (as calculated)$867,532 $858,463 $4,311,539 $1,945,825 $(21,606,202)$(2,156,954)
    
Non-PEO NEO Average Total Compensation Amount $ 2,255,795 1,604,322 3,509,439
Non-PEO NEO Average Compensation Actually Paid Amount $ 858,463 1,945,825 (2,156,954)
Adjustment to Non-PEO NEO Compensation Footnote These amounts are computed in accordance with Item 402(v) of Regulation S-K by deducting and adding the following amounts from the “Total” column of the SCT (pursuant to SEC rules, fair value at each measurement date is computed in a manner consistent with the fair value methodology used to account for share-based payments in our financial statements under GAAP):
202420232022
PEOAverage Non-PEO NEOsPEOAverage Non-PEO NEOsPEOAverage Non-PEO NEOs
Total Compensation from Summary Compensation Table$5,239,784 $2,255,795 $3,790,099 $1,604,322 $2,595,395 $3,509,439 
Adjustments for Equity Awards
Adjustments for grant date fair values of equity awards granted in the current year(4,158,659)(1,481,447)(2,804,021)(891,745)(1,624,400)(2,844,379)
Year-end fair value of unvested equity awards granted in the current year1,208,104 428,267 4,110,779 1,362,669 284,900 356,546 
Year-over-year difference of year-end fair values for unvested equity awards granted in prior years(1,732,748)(412,318)(198,377)(34,088)(18,018,970)(2,349,947)
Fair values at vest date for equity awards granted and vested in current year308,683 109,509 106,718 17,814 158,875 104,252 
Difference in fair values between prior year-end fair values and vest date fair values for equity awards granted in prior years2,368 (41,343)(693,659)(113,147)(5,002,002)(932,865)
Total Adjustments for Equity Awards(4,372,252)(1,397,332)521,440 341,503 (24,201,597)(5,666,393)
Compensation Actually Paid (as calculated)$867,532 $858,463 $4,311,539 $1,945,825 $(21,606,202)$(2,156,954)
    
Compensation Actually Paid vs. Total Shareholder Return
2021
    
Compensation Actually Paid vs. Net Income
2023
    
Total Shareholder Return Vs Peer Group
2021
    
Total Shareholder Return Amount $ 10.87 17.05 17.81
Net Income (Loss) $ (105,316,000) (132,493,000) (128,175,000)
PEO Name Mr. Hirsch    
Additional 402(v) Disclosure
The following table sets forth information regarding “compensation actually paid” to our principal executive officer, or PEO, Mr. Hirsch, and to our non-PEO NEOs for each applicable year. The identity of our NEOs other than Mr. Hirsch may vary year-over-year and the identity of which NEOs are included in this table is determined based on those executive officers who were NEOs for the years presented. Compensation actually paid to Mr. Hirsch and our other NEOs is impacted by the fair value of their equity incentive awards, which is calculated in accordance with the provisions of FASB
ASC Topic 718, Compensation—Stock Compensation. See Note 2 to our audited consolidated financial statements appearing in our 2023 Annual Report for a summary of the assumptions underlying the valuation of equity awards.
Shareholder return provides the value of common stock as of December 31, 2024, December 31, 2023, and December 31, 2022 assuming $100 was invested in our common stock after the market closed on December 31, 2020. 		   
PEO      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (4,372,252) 521,440 (24,201,597)
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (4,158,659) (2,804,021) (1,624,400)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,208,104 4,110,779 284,900
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (1,732,748) (198,377) (18,018,970)
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 308,683 106,718 158,875
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 2,368 (693,659) (5,002,002)
Non-PEO NEO      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (1,397,332) 341,503 (5,666,393)
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (1,481,447) (891,745) (2,844,379)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 428,267 1,362,669 356,546
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (412,318) (34,088) (2,349,947)
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 109,509 17,814 104,252
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (41,343) $ (113,147) $ (932,865)