Nature of the business (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 105,316	$ 132,493
Accumulated deficit	633,699	$ 528,383
Cash, cash equivalents and marketable securities	$ 267,300