Nature of the business and basis of presentation (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 28,361	$ 34,780
Accumulated deficit	556,744		$ 528,383
Cash, cash equivalents and marketable securities	$ 299,200