Property and equipment (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022
Property Plant And Equipment [Line Items]
Property and equipment	$ 15,192		$ 15,192		$ 15,523
Less: accumulated depreciation	(7,902)		(7,902)		(8,123)
Total property and equipment, net	7,290		7,290		7,400
Depreciation and amortization expense	447	$ 415	1,450	$ 1,155
Laboratory equipment
Property Plant And Equipment [Line Items]
Property and equipment	8,303		8,303		8,757
Leasehold improvements
Property Plant And Equipment [Line Items]
Property and equipment	4,766		4,766		4,682
Furniture and fixtures
Property Plant And Equipment [Line Items]
Property and equipment	1,181		1,181		1,181
Construction in progress
Property Plant And Equipment [Line Items]
Property and equipment	223		223		183
Office equipment
Property Plant And Equipment [Line Items]
Property and equipment	621		621		529
Computer equipment
Property Plant And Equipment [Line Items]
Property and equipment	$ 98		$ 98		$ 191