Nature of the business and basis of presentation (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 97,739	$ 90,990
Accumulated deficit	493,629		$ 395,890
Cash, cash equivalents and marketable securities	$ 246,400