Nature of the business and basis of presentation (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 70,702	$ 59,032
Accumulated deficit	466,592		$ 395,890
Cash, cash equivalents and marketable securities	$ 286,700