Nature of the business and basis of presentation (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 34,780	$ 31,620
Accumulated deficit	430,670		$ 395,890
Cash, cash equivalents and marketable securities	$ 305,000