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Net Loss per share
12 Months Ended
Dec. 31, 2022
Earnings Per Share [Abstract]  
Net Loss per share Net Loss per share
As described in Note 2, Summary of significant accounting policies, for periods in which the Company reports a net loss, potentially dilutive securities have been excluded from the computation of diluted net loss per share as their effects would be anti-dilutive. Therefore, the weighted average number of common shares outstanding used to calculate both basic and diluted net loss per share is the same. The Company excluded the following potential common shares presented based on amounts outstanding at period end, from the computation of diluted net loss per share for the periods indicated because including them would have had an anti-dilutive effect:
Years Ended December 31,
20222021
Options to purchase common stock6,993,052 5,983,425 
Basic and diluted loss per share is computed by dividing net loss by the weighted-average common shares outstanding (in thousands, except share and per share data):
Years Ended December 31,
20222021
Numerator:
Net loss —basic and diluted$(128,175)$(83,892)
Denominator:
Weighted-average common stock outstanding—basic and diluted48,861,665 46,041,733 
Net loss per share —basic and diluted$(2.62)$(1.82)