Marketable securities - Summary of marketable securities in unrealized loss position (Details) $ in Thousands	Jun. 30, 2022 USD ($) security	Dec. 31, 2021 security
Number of Securities
Marketable securities in continuous unrealized loss position for greater than 12 months, Number of securities | security		0
Total marketable securities in unrealized loss position, Number of securities | security	123
Fair Value
Total marketable securities in unrealized loss position	$ 339,111
Gross Unrealized Losses
Total marketable securities in unrealized loss position	$ (4,581)
Corporate debt securities
Number of Securities
Marketable securities in continuous unrealized loss position for less than 12 months, Number of securities | security	95
Marketable securities in continuous unrealized loss position for greater than 12 months, Number of securities | security	11
Fair Value
Marketable securities in continuous unrealized loss position for less than 12 months	$ 242,455
Marketable securities in continuous unrealized loss position for greater than 12 months	20,186
Gross Unrealized Losses
Marketable securities in continuous unrealized loss position for less than 12 months	(2,743)
Marketable securities in continuous unrealized loss position for greater than 12 months	$ (200)
U.S. government debt securities
Number of Securities
Marketable securities in continuous unrealized loss position for less than 12 months, Number of securities | security	10
Marketable securities in continuous unrealized loss position for greater than 12 months, Number of securities | security	1
Fair Value
Marketable securities in continuous unrealized loss position for less than 12 months	$ 45,908
Marketable securities in continuous unrealized loss position for greater than 12 months	4,871
Gross Unrealized Losses
Marketable securities in continuous unrealized loss position for less than 12 months	(1,069)
Marketable securities in continuous unrealized loss position for greater than 12 months	$ (129)
U.S. Treasury securities
Number of Securities
Marketable securities in continuous unrealized loss position for less than 12 months, Number of securities | security	6
Fair Value
Marketable securities in continuous unrealized loss position for less than 12 months	$ 25,691
Gross Unrealized Losses
Marketable securities in continuous unrealized loss position for less than 12 months	$ (440)