Marketable securities - Summary of marketable securities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Marketable securities, non-current:
Amortized Cost	$ 345,122	$ 376,130
Gross Unrealized Gains	0	1
Gross Unrealized Losses	(4,581)	(776)
Fair Value	340,541	375,355
Corporate debt securities
Marketable securities, current:
Amortized Cost	210,758	219,414
Gross Unrealized Gains	0	1
Gross Unrealized Losses	(1,723)	(250)
Fair Value	209,035	219,165
Marketable securities, non-current:
Amortized Cost	56,256	89,538
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(1,220)	(403)
Fair Value	55,036	89,135
U.S. government debt securities
Marketable securities, current:
Amortized Cost	20,989	5,006
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(257)	0
Fair Value	20,732	5,006
Marketable securities, non-current:
Amortized Cost	30,988	32,982
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(941)	(105)
Fair Value	30,047	32,877
U.S. Treasury securities
Marketable securities, current:
Amortized Cost	21,023	8,987
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(306)	(3)
Fair Value	20,717	8,984
Marketable securities, non-current:
Amortized Cost	5,108	20,203
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(134)	(15)
Fair Value	$ 4,974	$ 20,188