Nature of the business and basis of presentation (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 59,032	$ 43,551
Accumulated deficit	326,747		$ 267,715
Cash, cash equivalents and marketable securities	$ 397,800